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學習快評丨qibao666888　　研??(yan)究??(jiu)團?(tuan)隊?(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術?(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去?(qu)這?(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負??(fu)責??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應??(ying)的??(de)p21蛋?(dan)白??(bai)產??(chan)量??(liang)銳?(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍?(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速?(su)系??(xi)統?(tong)的??(de)關??(guan)鍵??(jian)制??(zhi)動??(dong)環??(huan)節??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白?(bai)??。這??(zhe)個?(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安?(an)全??(quan)鎖??(suo)”的??(de)關??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦?(dan)缺?(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小?(xiao)膠??(jiao)質??(zhi)細??(xi)胞?(bao)被??(bei)激??(ji)活??(huo)時?(shi)徹?(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子?(zi)的??(de)大??(da)規??(gui)模??(mo)爆??(bao)發??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴??(yan)重??(zhong)破?(po)壞??(huai)??。　　北??(bei)京??(jing)時??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華??(hua)大??(da)學??(xue)藥??(yao)學??(xue)院??(yuan)丁??(ding)勝??(sheng)教?(jiao)授??(shou)團??(tuan)隊??(dui)在??(zai)國??(guo)際??(ji)頂??(ding)級??(ji)學??(xue)術??(shu)期??(qi)刊??(kan)《Immunity》發??(fa)表??(biao)突??(tu)破??(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關??(guan)鍵??(jian)開??(kai)關??(guan)??，并??(bing)成??(cheng)功??(gong)從?(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準??(zhun)修??(xiu)復??(fu)該??(gai)系??(xi)統??(tong)的??(de)藥??(yao)物??(wu)小??(xiao)分??(fen)子??(zi)BMS265246??。??在??(zai)動??(dong)物?(wu)實??(shi)驗??(yan)中??(zhong)??，這??(zhe)種??(zhong)新??(xin)型?(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患?(huan)病??(bing)小??(xiao)鼠??(shu)的??(de)腦??(nao)部??(bu)炎??(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功?(gong)能??(neng)基??(ji)本?(ben)恢??(hui)復??(fu)正??(zheng)常??(chang)??。這??(zhe)項??(xiang)發??(fa)現??(xian)不?(bu)僅??(jin)為??(wei)學??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調??(tiao)控??(kong)非??(fei)分?(fen)裂?(lie)細??(xi)胞?(bao)功??(gong)能??(neng)提?(ti)供??(gong)了?(le)嶄?(zhan)新??(xin)的??(de)實?(shi)例??(li)??，更??(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路?(lu)徑??(jing)??。。